Our hero is "probabilistic assessor" Catalina Jones, who gains super-powers after a freak accident involving a graviton missile, a burrito and a microwave oven. With the help of her friend Xi Chen and her fiancee, she determines that her power is to cause unlikely events to occur, events whose probability is exactly 10²³⁵ to one against. Moreover, she builds a device to help her to determine precisely what events with this probability will occur at the present time in her present location.

There is actually not that much "explicit math" in the first four issues, even though math is important to the plot. Here is a list of the mathematical references I noticed: The cover of the first issue includes a long mathematical expression involving π and q (see image). In the third issue she and Xi Chen talk about using math to analyze her powers, and in fourth issue she determines that the bizarre events she has caused all have this precise probability. (Unbeknownst to Catalina, the mysterious figures responsible for the graviton accident know that the graviton passed through exactly 10²³⁵ alternate universes. Presumably, this will turn out to be relevant.) The cover of the fourth issue features a door with a warning sign reading "Danger Keep Out Hazardous Math Area".

Thanks to Kate Owens for bringing this comic book to my attention and for lending me her copies of the first four issues.