a list compiled by Alex Kasman (College of Charleston)
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In this television series about a medical doctor at a British university, a recurring character during the first season was a mathematician who was the doctor's roommate, Chen. Their "flat" was therefore filled with equations scribbled on blackboards, which were occasionally the subject of conversation. In one episode, the "maths" becomes more relevant when Chen's research is stolen by other mathematicians, but it generally had nothing to do with the plot.
[BTW Why does Peter Davison so frequently play "doctors" of some sort or other?!? From Doctor Who to the veterinarian in All Creatures...to the main role in this one, it almost seems as if he's been typecast.] 
More information about this work can be found at www.imdb.com. 
(Note: This is just one work of mathematical fiction from the list. To see the entire list or to see more works of mathematical fiction, return to the Homepage.) 

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Exciting News: The 1,600th entry was recently added to this database of mathematical fiction! Also, for those of you interested in nonfictional math books let me (shamelessly) plug the recent release of the second edition of my soliton theory textbook.
(Maintained by Alex Kasman, College of Charleston)